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KMID : 0606920110190010097
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Biomolecules & Therapeutics
2011 Volume.19 No. 1 p.97 ~ p.101
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Polyacetylene Compound from Cirsium japonicum var. ussuriense inhibits the LPS-Induced Inflammatory Reaction via Suppression of NF-κB Activity in RAW 264.7 Cells
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Kang Tae-Jin
Moon Jung-Sun
Lee Sook-Yeon
Yim Dong-Sool
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Abstract
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Cirsium japonicum var. ussuriense is known to have a variety of biological activities, including anti-infl ammatory, analgesic activity and antipyretic activity. In this study we investigated the role of polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense as an immune-modulator. PA was evaluated as inhibitors of some macrophage functions involved in the infl ammatory process. We tested the effect of PA on the production of pro-infl ammatory cytokines, interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) in murine macrophage cell line, RAW264.7. There was no effect on cytokine production of macrophages by PA itself. However, PA inhibited lipopolysaccharide (LPS)-induced IL-1β and TNF-α production by macrophages at a dose dependent manner. PA also suppressed the NO production of macrophages by LPS. LPS-induced NF-κB activity was decreased by treatment of PA. Therefore, these results suggest that PA has anti-infl ammatory effect by inhibiting the NF-κB activation.
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KEYWORD
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Polyacetylene compound, Cirsium japonicum var. ussuriense, Anti-inflammatory activity, RAW264.7 cell
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